Renal Indicators and Significance
Date :2020-01-09 Click :
As we know, the kidneys are one of our most important organs. Its main function are as following：
① Excrete urine, waste, poison and medicine residual.
② Regulate and maintain body fluid volume with elements. (water, osmotic pressure, electrolytes and etc.)
③ Keep balance of internal environment(blood pressure and endocrine).
If our kidneys function get damaged, we can see abnormal blood index when we do body test. Do you know the common seen figures of our kidneys?
1、Serum urea (BUN)
Serum urea is a metabolite of human protein which is discharged out through glomerular filtration. When our kidneys get damaged, glomerulus filtration rate(Gfr) comes down. So BUN level can reflect renal function.
Serum creatinine can partly indicate damage level of glomerulus filtration .When renal function is normal, creatinine excretion rate is in normal range. It means over 50% of kidneys function have been damaged when creatinine level begins to increase. If both creatinine and BUN level rise, it means kidney function damage is serious.When you find creatinine level reduces too much,you need pay attention to some diseases like amyotrophy, leukemia, anemia and liver function problem.
β2-microglobulin is a small molecular protein produced by lymphocytes, platelets and polymorphonuclear white blood cells, most of which are absorbed in proximal renal tubules. Its elevation means:
① Decreased renal function that may indicates some acute or chronic nephritis、renal failure、diabetic nephropathy、renal tumor and etc. It is more sensitive than serum creatinine in evaluating glomerulus filtration function.
② Original liver cancer、lung cancer、stomach cancer、multiple myeloma、malignant lymphoma and etc.
③ Autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis, autoimmune hemolytic anemia, and etc.
4、Uric acid Uric acid is the final product of purine metabolism which is mainly excreted by the kidneys. So we can judge kidney function through uric acid level. Increasing uric acid may also indicates gout, kidney disease and cancer.
As kidney disease patients, it is necessary to learn some knowledge, thus you can find the most suitable treatment for you.