What Symptoms Will You Have When You Get Nephrotic Syndrome
Date :2020-01-13 Click :
Nephrotic syndrome is an immune disorder which is featured with a lot of protein leakage. It can be divided to two main types:
1. Primary nephrotic syndrome, such as micropathological nephropathy, mesangial proliferative glomerulonephritis, focal segmental glomerulosclerosis, mesangial capillary glomerulonephritis, membranous nephropathy, etc.
2. Secondary nephrotic syndrome, such as allergic purpura nephritis, hepatitis b virus-associated nephritis, lupus nephritis, diabetic nephropathy, renal amyloidosis, myeloma nephropathy, lymphoma or solid tumor nephropathy, etc.
Besides plenty of protein leakage, you can also judge nephrotic syndrome from other symptoms.
•A large amount of proteinuria is a sign of nephrotic syndrome which mainly contains albumin, also plasma protein. Glomerular basement membrane permeability change is the basic cause of proteinuria. Changes of mechanical barrier and charge barrier, absorption and catabolism ability of renal tubular epithelial cells also have influence on the formation of proteinuria. Glomerular filtration rate, concentration of plasma protein and protein intake directly affects the level of proteinuria.
•Hypoproteinemia. When you are diagnosed by nephrotic syndrome and serum albumin is less than 30 g/L, liver will compound more albumin to make up insufficient serum albumin. When albumin compensatory of liver is not enough to compensate for the loss of urine protein quantity, hypoalbuminemia come out. So hypoalbuminemia and urinary protein excretion is not fully consistent.
•Edema. The most noticeable symptom of the patient is gradually increased systemic edema, which can be seen in the eyelid, face and ankle in the morning. With the development of the disease, edema affects the whole body, like pleural effusion, ascites, pericardial effusion, mediastinal effusion, scrotal or labial edema and pulmonary edema. In some serioius cases, patient’s eyes can not open; the head and neck become thick;the skin can be waxy pale.
•Hyperlipidemia. Hyperlipidemia is associated with low serum albumin level. LDL/HLDL will rise only when serum albumin is below 10 ~ 20g/L. Furthermore, when high density lipoprotein (HDL) is normal or drop and LDL/HDL ratio increases, the risk of arteriosclerotic complications will become high.
Through the above introduction, you should know the basic symptoms of nephrotic syndrome. Only know some of its symptoms can symptomatic treatment be given. Then you can achieve good treatment effect.